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Synthesis and Application of Glycopeptide and Glycoprotein Mimetics.

Glen Research is delighted to introduce a GalNAc modification strategy using a monomeric GalNAc support and the equivalent GalNAc phosphoramidite. Our experimental work has shown that these products are fully compatible with regular oligonucleotide synthesis and deprotection. Oligonucleotides containing GalNAc can be deprotected using standard procedures during which the acetyl protecting groups on the GalNAc group are removed. Glen Research offers these GalNAc C3 products under an agreement with AM Chemicals LLC.

Aziridines in Parallel- and Solid-Phase Synthesis.

Preparation, Characterization, and Application of Poly(vinyl alcohol)-graft-Poly(ethylene glycol) Resins: Novel Polymer Matrices for Solid-Phase Synthesis.

Advances in Solid-Phase Cycloadditions for Heterocyclic Synthesis.

Living Radical Polymerization as a Tool for the Synthesis of Polymer-Protein/Peptide Bioconjugates.

One of the most often asked questions is what region of a protein to synthesize to produce anti-peptide antisera. Although there is no correct answer for any protein, there are a number of computer programs derived from several publications that provide good approximations for immunogenic regions within proteins . These are available from the Rockefeller University Computer Services in the Smith Hall User Area.

Prior to finalizing your peptide sequence please consider the following points:

Peptides are synthesized on Protein Technologies "Symphony" instruments using FMOC based chemistry and uronium salt type activation methodologies, such as HATU/HOBt/DIEA activation. This chemistry provides for faster synthesis cycles, better coupling kinetics, and greatly improved coupling efficiencies. These improvements result in faster turnaround times and lower prices for peptide synthesis. Additionally, FMOC peptides can be cleaved using a trifluoroacetic acid/cation scavenger cocktail, obviating the need for costly and time consuming HF or TFMSA cleavages required for t-Boc peptide synthesis. At this time t-Boc synthesis is not used for the production of peptides in the Peptide Synthesis Laboratory.

M., Solid-phase synthesis of C-terminally modified peptides.

Formation of N-branched oligonucleotides as by-products in solid-phase oligonucleotide synthesis

Synthetic peptides have a wide variety of uses ranging from structure-function analysis of sites within the protein, binding assays, receptor agonists/antagonists, to immunogens for the production of antisera. Regardless of the specific application, all that is required from the investigator to initiate peptide synthesis is the sequence of the desired peptide and an account number. We will attempt to synthesize virtually any sequence provided by the investigators. The Peptide Synthesis Service provides a complete range of services including cleavage, HPLC purification, quality assurance analysis and a variety of amino acid derivatization/labeling techniques.

Although there have recently been significant advances in solid phase peptide synthesis, most notably the virtually universal transition from t-Boc to FMOC based chemistries, peptide synthesis still remains somewhat of an art, definitely not a routine process. In the past, particular amino acids or combinations of amino acids posed significant obstacles for synthesys, as did longer peptides. The new chemistries have shifted the synthetic problems to primarily sequence-based ones. While this has allowed the more routine synthesis of short peptides, and increased the potential for successful synthesis of longer peptides, prediction of problem regions is still often elusive. This makes stringent quality assurance measurements for every peptide synthesized at the PRC an essential part of the synthetic process. Each peptide delivered to an investigator is fully validated by LC-MS (liquid chromatography-mass spectrometry).

M., Synthesis of bio-inspired hybrid polymers using peptide synthesis and protein engineering.
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H., His6 tag-assisted chemical protein synthesis.

The enzyme is also regulated by covalent modification (adenylylation of a Tyrresidue), which results in an increase sensitivity to the cumulative feedbackinhibition by the above nine effectors. Adenylyltransferase is the enzyme whichcatalyzes both the adenylylation and deadenylylation of E. coli glutaminesynthetase, and this enzyme is complexed with a tetrameric regulatory protein, PII.Regulation of the adenylylation and its reverse occurs at the level of PII,depending upon the uridylylation of another Tyr residue, located on PII.When PII is uridylylated, glutamine synthetase is deadenylylated; thereverse occurs when UMP is covalently attached to the Tyr residue of PII.The level of uridylylation is, in turn, regulated by the activities of the twoenzymes, uridylyltransferase and uridylyl-removing enzyme, both located on thesame protein. Uridylyltransferase is activated by -ketoglutarateand ATP, while it is inhibited by glutamine and Pi.

Solid phase peptide synthesis of arginine ..

Nα- acyl arginine derivatives that contain basic amino acid (Arginine) as terminal amino acid have been prepared by peptide synthesis methods.

Solid-Phase Peptide Synthesis of Arginine-vasopressin …

Sep 5, 1988. The trmD operon of Escherichia coli encodes the ribosomal proteins S16 and L19, the tRNAm1G37methyltransferase and a 21,000 Mr protein. TRNA, and that the synthesis of ribosomal protein, like the synthesis of rRNA, is subject to the influence of the rel gene control system. In exponentially growing.

Keyword - Arginine biosynthesis (KW-0055) - UniProt

Histidine is special in that its biosynthesis is inherently linked to thepathways of nucleotide formation. Histidine residues are often found in enzymeactive sites, where the chemistry of the imidazole ring of histidine makes it anucleophile and a good acid/base catalyzer. We now know that RNA can havecatalytic properties, and there has been speculation that life was originallyRNA-based. Perhaps the transition to protein catalysis from RNA catalysisoccurred at the origin of histidine biosynthesis.

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