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Solid-phase oligonucleotide synthesis - ATDBio
One subtype of DNA microarrays can be described as substrates (nylon, glass, etc.) to which oligonucleotides have been bound at high density. There are a number of within the life sciences.
Oligonucleotides composed of DNA (oligodeoxyribonucleotides) are often used in the , a procedure that can greatly amplify almost any small piece of DNA. There, the oligonucleotide is referred to as a , allowing to extend the oligonucleotide and replicate the complementary strand.
Emerging Oligonucleotide Therapeutics - Discovery On …
The length of the oligonucleotide is usually denoted by "" (from meros, "part"). For example, a fragment of 25 bases would be called a 25-mer. Because oligonucleotides readily bind to their respective nucleotide, they are often used as for detecting DNA or RNA. Examples of procedures that use oligonucleotides include , , , (FISH), and the synthesis of artificial genes.
Oligonucleotides are chemically synthesized using building blocks, protected of natural or chemically modified or, to a lesser extent, of non-nucleosidic compounds. The oligonucleotide chain assembly proceeds in the direction from 3'- to 5'-terminus by following a routine procedure referred to as a "synthetic cycle". Completion of a single synthetic cycle results in the addition of one nucleotide residue to the growing chain. A less than 100% yield of each synthetic step and the occurrence of side reactions set practical limits of the efficiency of the process so that the maximum length of synthetic oligonucleotides hardly exceeds 200 nucleotide residues. and other methods can be used to isolate products with the desired sequence
Purification of oligonucleotides - Oligo synthesis experts
An oligonucleotide (from prefix oligo-, "having few, having little") is a short polymer, typically with twenty or fewer . Although they can be formed by of longer segments, they are now more commonly synthesized by polymerizing individual nucleotide precursors. Automated synthesizers allow the synthesis of oligonucleotides up to 160 to 200 bases.
Antisense oligonucleotides are single strands of DNA or RNA that are complementary to a chosen sequence. In the case of they prevent of certain strands by binding to them. Antisense DNA can be used to target a specific, complementary (coding or ) RNA. If binding takes places this DNA/RNA hybrid can be degraded by the enzyme .
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