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Synthesis and properties of new 9,10-anthraquinone …

This paper describes the synthesis and electrochemical reactivity of octanethiolate monolayer-protected Au cluster compounds (MPCs) in which some of the original octanethiolate monolayer has been substituted by place-exchange reactions with 1-(1,3-dithiapropyl)anthracene-9,10-dione. The mixed monolayer MPC can contain as many as 25 anthraquinone sites/cluster, which are all electroactive in rapid, successive one-electron reactions. The voltammetric behavior includes mass-transport-controlled charging of the electrical double layers of the Au cores, which are, in effect, diffusing nanoelectrodes. Mediated electrocatalytic reduction of a gem-dinitrocyclohexane by clusters bearing reduced anthraquinone sites yields eleetrocatalytic currents larger than those generated using freely diffusing anthraquinone radical anion monomer as mediator.

Synthesis of polyetherurethane cationomers with anthraquinone structure

N2 - This paper describes the synthesis and electrochemical reactivity of octanethiolate monolayer-protected Au cluster compounds (MPCs) in which some of the original octanethiolate monolayer has been substituted by place-exchange reactions with 1-(1,3-dithiapropyl)anthracene-9,10-dione. The mixed monolayer MPC can contain as many as 25 anthraquinone sites/cluster, which are all electroactive in rapid, successive one-electron reactions. The voltammetric behavior includes mass-transport-controlled charging of the electrical double layers of the Au cores, which are, in effect, diffusing nanoelectrodes. Mediated electrocatalytic reduction of a gem-dinitrocyclohexane by clusters bearing reduced anthraquinone sites yields eleetrocatalytic currents larger than those generated using freely diffusing anthraquinone radical anion monomer as mediator.

anthraquinone derivatives: synthesis …

A general method for the synthesis of benz[a]anthraquinones is reported

The synthesis of a series of anthraquinone moieties bearing symmetrical sulfur-linked substituents in the 1 and 5 positions is described. These compounds were evaluated for their ability to inhibit the growth of suspended rat glioma C6 cells and human hepatoma G2 cells, respectively. In addition, the redox property of the compounds was determined based on the inhibition of lipid peroxidation in model membranes. Compounds 2a and 2h in this series compared favorably and exhibited the most potent cytotoxicity (0.02, 0.05 μM) against C6 cells in the XTT colorimetric assay. As far as redox properties are concerned, all bis-thio-anthraquinones show potential lipid peroxidation in model membranes very close to that of mitoxantrone (MX), and 2a, 2d, 2e, 2i, 2j, and 2k have more potential than that of MX. The lack of cytotoxicity of compound 2i cannot be related to lipid peroxidation, but the steric and electronic properties of the side-chain substituent maybe impair effective recognition of the cleavable complex. In contrast to MX, 2a and 2h are cytotoxic in rat glioma C6 cells and do not enhance lipid peroxidation in model membranes.

N2 - The synthesis of a series of anthraquinone moieties bearing symmetrical sulfur-linked substituents in the 1 and 5 positions is described. These compounds were evaluated for their ability to inhibit the growth of suspended rat glioma C6 cells and human hepatoma G2 cells, respectively. In addition, the redox property of the compounds was determined based on the inhibition of lipid peroxidation in model membranes. Compounds 2a and 2h in this series compared favorably and exhibited the most potent cytotoxicity (0.02, 0.05 μM) against C6 cells in the XTT colorimetric assay. As far as redox properties are concerned, all bis-thio-anthraquinones show potential lipid peroxidation in model membranes very close to that of mitoxantrone (MX), and 2a, 2d, 2e, 2i, 2j, and 2k have more potential than that of MX. The lack of cytotoxicity of compound 2i cannot be related to lipid peroxidation, but the steric and electronic properties of the side-chain substituent maybe impair effective recognition of the cleavable complex. In contrast to MX, 2a and 2h are cytotoxic in rat glioma C6 cells and do not enhance lipid peroxidation in model membranes.

Anthraquinone–chalcone hybrids: Synthesis ..

Two new phosphoramidite building blocks for DNA synthesis were synthesized from 1,5- and 2,6-dihydroxyanthraquinones through alkylation with 3-bromo-1-propanol followed by DMT-protection. The novel synthesized 1,5- and 2,6-disubstituted anthraquinone monomers H15 and H26 are incorporated into a G-quadruplex by single and double replacements of TGT and TT loops. Monomers H15 and H26 were found to destabilize G-quadruplex structures for all single replacements of TGT or TT loops. The largest destabilization was observed when H26 linker replaced a TT loop. In contrast, the presence of anthraquinone monomers in two TT loops led to 1–18 °C increase in their thermal stabilities, depending on linker attachment geometry of the monomers. The presence of H15 and H26 linkers replacing two TT loops results in the highest stabilization of the G-quadruplex structure by 18.2 °C. Circular dichroism spectroscopy of all anthraquinone-modified quadruplexes revealed no change of the antiparallel structure when compared with the wild type under potassium buffer conditions. The significantly increased thermostabilities were interpreted by molecular modeling of anthraquinone-modified G-quadruplexes.

AB - The synthesis of a series of anthraquinone moieties bearing symmetrical sulfur-linked substituents in the 1 and 5 positions is described. These compounds were evaluated for their ability to inhibit the growth of suspended rat glioma C6 cells and human hepatoma G2 cells, respectively. In addition, the redox property of the compounds was determined based on the inhibition of lipid peroxidation in model membranes. Compounds 2a and 2h in this series compared favorably and exhibited the most potent cytotoxicity (0.02, 0.05 μM) against C6 cells in the XTT colorimetric assay. As far as redox properties are concerned, all bis-thio-anthraquinones show potential lipid peroxidation in model membranes very close to that of mitoxantrone (MX), and 2a, 2d, 2e, 2i, 2j, and 2k have more potential than that of MX. The lack of cytotoxicity of compound 2i cannot be related to lipid peroxidation, but the steric and electronic properties of the side-chain substituent maybe impair effective recognition of the cleavable complex. In contrast to MX, 2a and 2h are cytotoxic in rat glioma C6 cells and do not enhance lipid peroxidation in model membranes.

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eBioChem - Leading biochemical marketplace with …

AB - This paper describes the synthesis and electrochemical reactivity of octanethiolate monolayer-protected Au cluster compounds (MPCs) in which some of the original octanethiolate monolayer has been substituted by place-exchange reactions with 1-(1,3-dithiapropyl)anthracene-9,10-dione. The mixed monolayer MPC can contain as many as 25 anthraquinone sites/cluster, which are all electroactive in rapid, successive one-electron reactions. The voltammetric behavior includes mass-transport-controlled charging of the electrical double layers of the Au cores, which are, in effect, diffusing nanoelectrodes. Mediated electrocatalytic reduction of a gem-dinitrocyclohexane by clusters bearing reduced anthraquinone sites yields eleetrocatalytic currents larger than those generated using freely diffusing anthraquinone radical anion monomer as mediator.

handprint : synthetic organic pigments

Deoxyribonucleic acid, DNA is the source of various genetic information and is currently one of the most important and studied biological receptor. Lately, a wide range of chemotherapeutic agents are known wherein they affect cell division or DNA synthesis, leading to inhibition of cell growth and cell death. Out of various agents anthraquinone, having a planar tricyclic structure is the backbone of many known antitumor drugs like doxorubicin and mitoxantrone capable of targeting at the molecular/DNA level. This review embraces discussion on DNA-binding molecules with special attention to anthraquinone based compounds having application in anticancer activity by DNA damage mechanism. The review also compiles the work reported on anthraquinone based molecule in molecular imaging.

Electrochemical routes for industrial synthesis - SciELO

In addition to the surgical removal of tumor tissue, another mode of pretreatment includes chemotherapy, radiotherapy and immuno-therapy. There is continuing interest in the development of new agents in which the small molecule tricyclic anthraquinone structural motif represents an attractive target for the rational design of new anticancer agents due to its central role in the control of cellular proliferation [46, 47]. A wide range of chemotherapeutic agents are known wherein they affect cell division or DNA synthesis leading to inhibition of cell growth and cell death.

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