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difference between ankylosing spondylitis and spondylolisthesis?
No definite disease-modifying treatment exists for individuals with ankylosing spondylitis (AS). Early diagnosis is important. As with any chronic disease, patient education is vital to familiarize the patient with the symptoms, course, and treatment of the disease. Treatment measures include pharmacologic, surgical, and physical therapy.
Ankylosing spondylitis (AS) is a chronic, multisystem inflammatory disorder primarily involving the sacroiliac (SI) joints and the axial skeleton. Other clinical manifestations include peripheral arthritis, enthesitis, and extra-articular organ involvement.[13, 14, 15, 16] AS has been designated by various names, including rheumatoid spondylitis in the American literature, spondyloarthrite rhizomegalique in the French literature, and the eponyms Marie-Strümpell disease and von Bechterew disease.
Ankylosing spondylitis: Symptoms, treatments, and causes
Ankylosing spondylitis (AS), a spondyloarthropathy, is a chronic, multisystem inflammatory disorder involving primarily the sacroiliac (SI) joints and the axial skeleton. The outcome in patients with a spondyloarthropathy, including AS, is generally good compared with that in patients with a disease such as rheumatoid arthritis. See the image below.
Sagittal imbalance of the spine is mainly related to any underlying pathology causing loss of lumbar lordosis (LL) such as multilevel degenerative disk disease, ankylosing spondylitis, diffuse idiopathic skeletal hyperostosis, osteoporosis, tumor, trauma, or infection (Figure 3). Secondary causes include iatrogenic flat back syndrome being attributed to the use in the past of distraction instrumentations such as the Harrington rods[14,15]. Nowadays iatrogenic flat back syndrome is more frequent due to lack of recreating the appropriate LL accordingly to the patient’s PI. In other cases loss of LL appears following spinal fusion surgery through an area of pseudarthrosis or through a degenerated segment adjacent to a previous fusion.
spondylitis or spondylosis | Ankylosing Spondylitis
Patient education is essential in disease management. Teach patients about the long-term nature of the illness and the use and toxicities of medications. Inform patients that proper exercise programs are useful in reducing symptoms and increasing ROM. For patient education information, see the Ankylosing Spondylitis Directory.
Although AS is associated with new bone formation at sites of spinal and peripheral enthesitis, osteopenia and osteoporosis have been documented in patients with long-standing spondylitis, resulting in an increased risk of fracture. Patients with AS who have severe spondylitis and who present with acute exacerbations of back or neck pain should be re-evaluated for possible fracture, especially in the setting of trauma. Standard radiography may not be revealing; computed tomography (CT) or MRI may be required to aid in diagnosis.
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What's the difference between Ankylosing Spondylitis …
Guidelines on treatment for ankylosing spondylitis (AS) and nonradiographic axial spondyloarthritis have been issued by the American College of Rheumatology.
The Difference Between Spondylitis and Spondylosis
Clinical Context: Etanercept consists of a fusion protein of the extracellular portion of the p75 TNF-α receptor and the Fc portion of immunoglobulin G (IgG). It inhibits TNF-α, reducing inflammation and symptoms of ankylosing spondylitis. It is given as a subcutaneous (SC) injection and is available in a prefilled syringe, an autoinjector, or lyophilized powder. It is also approved for rheumatoid arthritis, PsA, psoriasis, and juvenile idiopathic arthritis.
Spondylolisthesis; Spondylosis; ..
Clinical Context: Certolizumab pegol is a recombinant humanized anti-human TNF-α neutralizing antibody. It inhibits TNF-α, reducing inflammation and symptoms of ankylosing spondylitis. It is given as a subcutaneous injection and is available as a powder for injection. It is FDA-approved for active ankylosing spondylitis, and is also indicated for Crohn Disease, rheumatoid arthritis, and psoriatic arthritis.
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