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Amyloid Hypothesis and Alzheimer's Disease - …
The Medium, November 2017
According to Uma Naidoo, turmeric is an ingredient found in curry that appears to be responsible for de-plaguing the brain. Naidoo also explains that turmeric, also referred to as "Indian gold," has properties that benefit the brain, making you almost as bright as its own fiery complexion. The ingredient responsible for this powerful herb's effects on the brain is known as curcumin. Naidoo says, “Curcumin has been found to possess neuroprotective properties, and may help shield the brain against Alzheimer’s disease (AD) by binding to and eliminating toxic beta-amyloid plaques, which are a hallmark of AD."
Sci-News, February 2018
Curcumin has previously been shown to have anti-inflammatory and antioxidant properties in lab studies. It also has been suggested as a possible reason that senior citizens in India, where curcumin is a dietary staple, have a lower prevalence of Alzheimer’s disease and better cognitive performance. “The people who took curcumin experienced significant improvements in their memory and attention abilities, while the subjects who received placebo did not,” Dr. Small said. “In memory tests, the people taking curcumin improved by 28% over the 18 months. Those taking curcumin also had mild improvements in mood, and their brain PET scans showed significantly less amyloid and tau signals in the amygdala and hypothalamus than those who took placebos.”
The Amyloid Hypothesis of Alzheimer's Disease: …
In , brain cells responsible for processing, storing, and receiving information become damaged and die. is suspected to play a part in this destruction. The "amyloid hypothesis" states that problems with increased levels of beta-amyloid cause Alzheimer's disease. Special molecules called proteins cut a large protein called Amyloid Precursor Protein () into smaller sections, one of these being beta-amyloid. Beta-amyloid is stickier than other fragments causing it to clump together into amyloid plaques. These plaques disrupt neurons by interfering with communication between them, and the cells eventually die.
Blasting News, February 2018
Turmeric -- The spice that gives curry that yellow coloring. This powerful herb's main ingredient is curcumin, a natural anti-inflammatory which the body needs to fight off bacteria that are harmful. Along with the increased production of antioxidants and a great way to fight heart disease, another important benefit of taking Turmeric is the growth hormone called Brain-Derived Neurotrophic Factor. According to the US National Library of Medicine, decreased levels of BDNF can lead to brain disease and decreased functions in the brain. Curcumin can increase levels of BDNF, which can delay or even reverse many brain diseases or age-related decreases in brain function. You will want to add this to your supplement routine, as curcumin makes up only three percent of Turmeric, so taking it as a supplement is better.
Amyloid Cascade Hypothesis In Alzheimer's Disease
Whole Foods Magazine, February 2018
Results of the study are as follows: Memory function of those who’d taken curcumin improved by 28% on average over the 18 months. In contrast, the control group’s scores rose slightly (possibly because they got more familiar with the tests) and then declined. The depression scores of those taking curcumin also improved; the control group’s didn’t change. Brain scans revealed significantly less amyloid and tau accumulation in two brain regions of the participants taking curcumin — the amygdala and hypothalamus, which control anxiety, memory, decision-making, and emotion.
Doctor Oz, February 2018
UCLA researchers find consumption of curcumin helps mood and memory. Forty adults with mild memory complaints were randomly selected to ingest curcumin twice daily or a placebo for 18 months. They underwent cognitive assessments and PET scans to test amyloid in the brain, which is associated with negative effects on memory and emotional functions. Those taking curcumin improved their memory tests by twenty-eight percent, demonstrated mild mood improvements, and showed far smaller levels of amyloid than the placebo group. A follow-up study will explore the possibility of curcumin possessing antidepressant effects and whether it can help your genetic risk for Alzheimer’s. These findings back up the far lower rate of Alzheimer’s in India’s senior citizens, whose diet is high in curcumin.
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The amyloid hypothesis of Alzheimer's..
Science Trends, November 2017
It has been suggested that the compound curcumin helps the immune system destroy amyloid plaque, reducing the production of inflammatory cytokines. In doing so, brain function deterioration is reduced, slowing down the development of Alzheimer's disease. Epidemiological studies have looked at the neuroprotective effect of curcumin and have demonstrated that regular consumption has reduced other cognitive deficits in the elderly. Over the years curcumin has been a main focus for research regarding its strong anti-tumor effects. In fact, several preclinical trials have demonstrated curcumin to have both chemopreventive and anti-tumor effects against certain types of cancer. This naturally occurring polyphenolic compound recently has shown promise as a dietary therapy for pancreatic cancer. Of course, it shouldn't be thought of as a primary means for treating cancer, but it may reduce tumor promotion and minimize the spread of cancer. Turmeric has anti-inflammatory abilities containing more than two dozen compounds which may help relieve osteoarthritis pain. Again, it’s the compound curcumin that works as an anti-inflammatory agent. Clinical studies have found that curcumin provided protection to joint inflammation in individuals with osteoarthritis. Ulcerative colitis is a chronic, inflammatory bowel disease causing inflammation in the digestive tract. The disease tends to flare up and subside at random. Studies have shown people with ulcerative colitis who took curcumin had a significantly lower relapse rate than people who did not take curcumin. A meta-analysis showed curcumin had a high effect in reducing symptoms of depression, such as irritable mood, reduced interest in pleasurable activities, fatigue or feelings of worthlessness. The analysis suggests that curcumin could possibly have a role in treating the symptoms of major depression.
Alzheimer's Disease: Return of the Prion Hypothesis
Pop Sugar, February 2018
Research published in the journal Oncogene found that turmeric is actually a more effective anti-inflammatory than over-the-counter pain relievers like aspirin and ibuprofen. ADVERTISEMENT This is a modal window. The media could not be loaded, either because the server or network failed or because the format is not supported. Turmeric can also be used to increase levels of brain-derived neurotrophic factor (BDNF), which is a growth hormone in the brain that, when low, is responsible for increased risk of Alzheimer's disease, depression, and a host of other mental ailments. The curcumin in turmeric has also been proven to reverse symptoms of heart disease. Many other studies have found a parallel function and effect of the substance on your heart as compared to exercise.
The β-Amyloid Hypothesis in Alzheimer's Disease: …
Health Spectator, February 2018
Daily consumption of curcumin improves the memory and mood of people with mild, age-related memory loss, according to a new study by the University of California, Los Angeles. The research, which has been published the American Journal of Geriatric Psychiatry, examined the effects of an easily absorbed curcumin supplement on memory performance in people without dementia, as well as curcumin’s impact on the microscopic plaques and tangles in the brains of people with Alzheimer’s. Found in turmeric, curcumin has previously been shown to have anti-inflammatory and antioxidant properties in lab studies. It also has been suggested as a possible reason that senior citizens in India, where curcumin is a dietary staple, have a lower prevalence of Alzheimer’s and better cognitive performance. The people who took curcumin experienced significant improvements in their memory and attention abilities, while the subjects who received placebo did not. In memory tests, the people taking curcumin improved by 28 per cent over the 18 months. Those taking curcumin also had mild improvements in mood, and their brain PET scans showed significantly less amyloid and tau signals in the amygdala and hypothalamus than those who took placebos.
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