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The oral LD50 of 3-chloro-1,2-propanediol in rats is 150 mg/kg bw.

8.8.2 Role of oxidation When purified cis-1,3-dichloropropene was heated for a few hours in an oxygen atmosphere, in either the light or dark, the non- mutagenic cis-1,3-dichloropropene became strongly mutagenic.

The results of studies of genotoxicity with 3-chloro-1,2-propanediol are summarized in Table 2.

Se ha detectado 1,3- dicloropropeno en "aguas subterráneas altas" (hasta 2 m por debajo de la superficie), pero no en las profundas, que son las que suelen utilizarse para beber.

1,3-Dichloropropene can be taken up by crops.

Es poco probable la bioacumulación de 1,3-dicloropropeno, debido a su solubilidad relativamente alta en agua (< 1 g/kg), al bajo log P del coeficiente de reparto octanol/agua y a la eliminación rápida en mamíferos y otros organismos.

La distribución del 1,3-dicloropropeno en los compartimentos del suelo depende de la presión del vapor, el coeficiente de difusión, la temperatura y el contenido de humedad del mismo.

Unchanged 1,3-dichloropropene is not found in the urine.

En el agua, el 1,3-dicloropropeno tiende a desaparecer con rapidez, debido a su solubilidad relativamente baja en ella y su elevada volatilidad; se han notificado semividas de menos de 5 h.

La formulación comercial del 1,3-dicloropropeno es una mezcla de isómeros cis y trans (aproximadamente en proporciones iguales), que forman un líquido entre incoloro y ámbar, con un olor penetrante e irritante, parecido al del cloroformo.

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Birds are relatively non-sensitive to 1,3- dichloropropene.

Les deux principaux constituants, le 1,3-dichloropropène et le 1,2- dichloropropane sont rapidement éliminés, essentiellement dans l'urine et en moindre proportion, dans l'air expiré.

Phenoxymethyl oxirane (122-60-1)

Le transport, la distribution et la destinée des principaux constituants du MIX D/D dans l'air, l'eau et le sol sont décrits à la section 4 des chapitres consacrées au 1,3-dichloropropène et au 1,2-dichloropropane.

Recoveries of 1,3-dichloropropenes were in the range of 1.8-18 mg/m3.

* Environnement: Il est improbable que le 1,2-dichloropropane s'accumule dans l'environnement à des concentrations écologiquement nocives lorsqu'on l'utilise à la dose recommandée.

Phosphonic acid, (2,2,2-trichloro-1-hydroxyethyl)-, dimethyl ester

On a fait état de plusieurs cas de dermatite ou de sensibilisation cutanée chez des travailleurs qui utilisaient des solvants contenant du 1,2-dichloropropane.

Methanone, bis(2-hydroxy-4-methoxyphenyl)-

Le 1,2-dichloropropane provoque des aberrations chromosomiques et des échanges entre chromatides soeurs dans les cellules ovariennes de hamster chinois; il y a également accroissement des échanges entre chromatides soeurs dans des cellules V79 de hamster chinois en présence de 1,2- dichloropropane.

Pure 1,3-dichloropropene was added at 35 µlitre/kg moist soil.

Après administration de 1,2-dichloropropane par voie orale à des rats à raison de 2 mg/kg, on a constaté une forte diminution du glutathion tissulaire.

1,2-Benzenedicarboxylic acid, mono(dimethylcyclohexyl) ester

La bioaccumulation du 1,2-dichloropropane est improbable en raison de sa forte solubilité dans l'eau (2,7 g/kg) et de la faible valeur de son coefficient de partage entre l'octanol et l'eau (log Kow).

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