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CiteULike: The 2R hypothesis: an update.

which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background: Within the bilaterians, the appearance and evolution of vertebrates is accompanied by enormous changes in anatomical, morphological and developmental features. This evolution of increased complexity has been associated with two genome duplications (2R hypothesis) at the origin of vertebrates. However, in spite of extensive debate the validity of the 2R hypothesis remains controversial. The paucity of sequence data in early years of genomic era was an intrinsic obstacle in tracking the genome evolutionary history of chordates. Hypothesis: In this article I review the 2R hypothesis by taking into account the recent availability of genomic sequence data for an expanding range of animals. I argue here that genetic architecture of lower metazoans and representatives of major vertebrate and invertebrate lineages provides no support for the hypothesis relating the origin of vertebrates with widespread gene or genome duplications. Conclusion: It appears that much of the genomic complexity of modern vertebrates is very ancient likely predating the origin of chordates or even the Bilaterian-Nonbilaterian divergence.

2R hypothesis : Wikis (The Full Wiki)

The 2R hypothesis or Ohno'shypothesis, first proposed by in 1970,is a contested hypothesis in and suggesting thatthe genomes of the early lineage underwent one or morecomplete , and thus modernvertebrate genomes reflect . The name derives fromthe 2 rounds of duplication hypothesizedby a 1994 version, and the term 2R hypothesis was probablycoined in 1999; variations in the number of duplications typicallystill are referred to as examples of the 2R hypothesis.Since Ohno proposed the first version of it in Evolution byGene Duplication, the 2R hypothesis has been the subject ofmuch research, but even with recent data from the , itremains a matter of scientific dispute.

macrosynteny; 2R Hypothesis; vertebrate ..

2R hypothesis: Ronald Cohn Jesse Russell: Books - …

Ohno presented the first version of the 2R hypothesis as part of his larger argument for the general importance of in . Based on relative genome sizes, he suggested that ancestral fish or amphibians had undergone at least one and possibly more cases of "tetraploid evolution". He later added to this argument the evidence that most in vertebrates do not demonstrate . Ohno argued that linkage should be expected in the case of individual tandem duplications (in which a duplicate gene is added adjacent to the original gene on the same chromosome), but not in the case of chromosome duplications.

The 2R hypothesis saw a resurgence of interest in the 1990s, with multiple suggestions for the time and number of duplications. Estimates for the dates of duplication events range from before 640 million years ago to after 450 million years ago. One argument for the hypothesis relies on the number of genes in mammals, which was previously estimated at around four times the number in invertebrate genomes (though more recent estimates are less than half that). Some analyses of gene families in human chromosomes have shown patterns that are not consistent with the 2R hypothesis. has produced some results that, while not supportive of the hypothesis, do not rule it out. According to a 2001 review of the subject by Wojciech Makałowski, "the hypothesis of whole genome duplications in the early stages of vertebrate evolution has as many adherents as opponents"; Makałowski argues that the overall balance of current evidence seems to be against it, but that it is not easily falsifiable because it can be modified to accommodate a wide range of data. Others analyzing duplications in the draft human genome sequence have claimed that genome data provides evidence of "extensive duplication" and that the parsimony tests that cast doubt on the hypothesis are of questionable validity. A review in 2007 by Masanori Kasahara states that there is now "incontrovertible evidence supporting the 2R hypothesis" and that "a long-standing debate on the 2R hypothesis is approaching the end".

Cosmic censorship hypothesis - Wikipedia

However, in spite of extensive debate the validity of the 2R hypothesis remains controversial

The 2R hypothesis or Ohno's hypothesis, first proposed by in 1970, is a contested hypothesis in and suggesting that the genomes of the early lineage underwent one or more complete , and thus modern vertebrate genomes reflect . The name derives from the of duplication hypothesized by a 1994 version, and the term was probably coined in 1999; variations in the number of duplications typically still are referred to as examples of the 2R hypothesis. Since Ohno proposed the first version of it in , the 2R hypothesis has been the subject of much research, but even with recent data from the , it remains a matter of scientific dispute.

Structural validity was evaluated by means of factor analysis, according to the degree of similarity between the hypothetical structure of the questionnaire conceived by researchers and the actual observed data. Results showed the KMO measure to be 0.786 and the Bartlett's spherical check to be χ2 = 198.11 and P = 0.000, which taken together, indicated that the samples in this study were suitable for factor analysis. Factor analysis results indicated that when two component summary scores, the PCS and the MCS, were extracted from those of the eight domains whose characteristic roots were > 1 or approaching 1, the accumulative contribution rate was up to 73.6%. As shown in Table , the PCS has larger factor loads on PF, RP and BP domains with high correlation, and lower factor loads on RE and MH domains with low correlation in accordance with the theoretical hypothesis. The MCS has larger factor loads on VT, RE and MH domains with high correlation, but the social function domain where the factor loads for the MCS for the observed data were slightly low and appeared as only a moderate correlation that was not identical with the hypothesis. The correlation coefficient (r > 0.50) for each item and its related domain, obtained by the correlation coefficient model, was relatively high, indicating good structural validity (Table ).

2R hypothesis - Wikidata
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10.1139/facets-2017-0063 - FACETS Journal

According to Hokamp et al. (2003),the version of the genome duplication hypothesis from which 2Rhypothesis takes its name appears in Holland et al.(1994)and the term was coined in Hughes (1999).

Correlation | Real Statistics Using Excel

Ohno presented the first version of the 2R hypothesis as part ofhis larger argument for the general importance of in . Based on relative genome sizes, hesuggested that ancestral fish or amphibians had undergone at leastone and possibly more cases of "tetraploid evolution". He lateradded to this argument the evidence that most in vertebrates do notdemonstrate . Ohno argued thatlinkage should be expected in the case of individual tandemduplications (in which a duplicate gene is added adjacent to theoriginal gene on the same chromosome), but not in the case ofchromosome duplications.

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The critical values of K-S statistic can be found at An Application: The daily sales of the two subsidiaries of The PC & Accessories Company are shown in the following table, with n1 = 44, and n2 = 54:

See also ' Common Concepts in Statistics ' and ‘ …

vertebrate novelties; neural crest; gastrula organiser; living fossil; macrosynteny; 2R Hypothesis; vertebrate new head; regulatory networks; genetic toolkit; chordate ancestor

Pharmacologic use of glucocorticoids - UpToDate

Following the above process for this test, the K-S statistic is 0.421 with the p-value of 0.0009, indicating a strong evidence against the null hypothesis.

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